The YEATS Domain Epigenetic Reader Proteins ENL and AF9 and Their Therapeutic Value in Leukemia

The MLLT1 gene, which encodes the eleven-nineteen-leukemia (ENL) protein, is located on chromosome 19p13.3 and shares high sequence homology with its human paralog, MLLT3 (encoding the AF9 protein). Over thirty years ago, the discovery of the t(11;19) (q23;p13.3) (MLL1-MLLT1) and t(9;11) (p22;q23) (MLL1-MLLT3) translocations marked our introduction to these proteins as two of the most common MLL fusion partners, representing roughly 13% and 19% of the MLL-rearranged (MLL-r) cases across all ages [1 –4] (Figure 1A).
Source: Experimental Hematology - Category: Hematology Authors: Tags: Perspective Source Type: research