Impact of cross-ancestry genetic architecture on GWASs in admixed populations

Genome-wide association studies (GWASs) are an important tool for disease mapping but are under-explored for populations of individuals with mixed genetic ancestries (admixed populations). We provide considerations for method selection and show that differences in allele frequency and/or causal effects by ancestry impact statistical power for GWASs in admixed populations.

Source: The American Journal of Human Genetics - May 23, 2023 Category: Genetics & Stem Cells Authors: Rachel Mester, Kangcheng Hou, Yi Ding, Gillian Meeks, Kathryn S. Burch, Arjun Bhattacharya, Brenna M. Henn, Bogdan Pasaniuc Tags: Article Source Type: research