Isoryanodane diterpene derivatives from < em > Barringtonia macrocarpa < /em >

Nat Prod Res. 2023 May 31:1-6. doi: 10.1080/14786419.2023.2217467. Online ahead of print.ABSTRACTFrom the MeOH residue of Barringtonia macrocarpa branches and leaves, one new isoryanodane diterpene, barringisol (1), and two new isoryanodane diterpene glucosides, barringisosides A and B (2 and 3), were obtained using various chromatographic isolations. The structural characterization was confirmed by spectroscopic methods including 1D, 2D NMR and HR-ESI-QTOF-MS. This is the first isolation of isoryanodane diterpene derivatives from Barringtonia species. Moreover, the in vitro cytotoxicity of 1-3 on three human cancer cell lines (HepG2, LNCaP and MCF7) was also accessed using SRB assays.PMID:37254840 | DOI:10.1080/14786419.2023.2217467

Source: Natural Product Research - May 31, 2023 Category: Biochemistry Authors: Pham Thi Mai Huong Pham Thi Cham Le Thi Vien Tran Thi Hong Hanh Nguyen The Cuong Dang Vu Luong Tran Hong Quang Nguyen Xuan Cuong Nguyen Hoai Nam Chau Van Minh Source Type: research