The GM-CSF/CCL17 pathway in obesity-associated osteoarthritic pain and disease in mice

We have previously identified a granulocyte macrophage-colony stimulating factor (GM-CSF)/C-C motif ligand 17 (CCL17) pathway in monocytes/macrophages, in which GM-CSF regulates the formation of CCL17 and it is important for an experimental osteoarthritis (OA) model. We explore here in additional OA models, including in the presence of obesity, such a requirement for this pathway.

Source: Osteoarthritis and Cartilage - May 22, 2023 Category: Rheumatology Authors: Heonsu Shin, Varun Prasad, Tanya Lupancu, Shveta Malik, Adrian Achuthan, Mark Biondo, Bronwyn A. Kingwell, Manja Thiem, Marlene Gottschalk, Heike Weighardt, Irmgard F örster, Richard de Steiger, John A. Hamilton, Kevin M.-C. Lee Source Type: research