Cancers, Vol. 15, Pages 2861: Partial Laryngectomy for pT4a Laryngeal Cancer: Outcomes and Limits in Selected Cases

Cancers, Vol. 15, Pages 2861: Partial Laryngectomy for pT4a Laryngeal Cancer: Outcomes and Limits in Selected Cases Cancers doi: 10.3390/cancers15102861 Authors: Giovanni Succo Andy Bertolin Izabela Costa Santos Martina Tascone Marco Lionello Marco Fantini Andressa Silva de Freitas Ilaria Bertotto Andrea Elio Sprio Giuseppe Sanguineti Fernando Luiz Dias Giuseppe Rizzotto Erika Crosetti A large multi-institutional case series of laryngeal cancer (LC) T4a was carried out, including 134 cases treated with open partial horizontal laryngectomies (OPHL) +/− post-operative radiation therapy (PORT). The goal was to understand better whether OPHL can be included among the viable options in selected pT4a LC patients who refuse a standard approach, represented by total laryngectomy (TL) + PORT. All 134 patients underwent OPHL type I (supraglottic), II (supracricoid), or III (supratracheal), according to the European Laryngological Society Classification. Comparing clinical and pathological stages showed pT up-staging in 105 cases (78.4%) and pN up-staging in 19 patients (11.4%). Five-year data on overall survival, disease-specific survival, disease-free survival, freedom from laryngectomy, and laryngo-esophageal dysfunction-free survival (rate of patients surviving without a local recurrence or requiring total laryngectomy and without a feeding tube or a tracheostomy) were, respectively, 82.1%, 89.8%, 75.7%, 89.7%, and 78.3%. Overall, compli...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research