Glut10 restrains neointima formation by promoting SMCs mtDNA demethylation and improving mitochondrial function

Neointimal hyperplasia is a major clinical complication of coronary artery bypass graft and percutaneous coronary intervention. Smooth muscle cells (SMCs) plays a vital roles in neointimal hyperplasia development and undergo complex phenotype switching. Previous studies have linked glucose transporter member 10(Glut10) to the phenotypic transformation of SMCs. In this research, we reported that Glut10 helps maintaining the contractile phenotype of SMCs. The Glut10-TET2/3 signaling axis can arrest neointimal hyperplasia progression by improving mitochondrial function via promotion of mtDNA demethylation in SMCs.

Source: Translational Research - May 21, 2023 Category: Research Authors: Qi Wu, Zhipeng Hu, Zhiwei Wang, Yanjia Che, Min Zhang, Sihao Zheng, Kai Xing, Xiaohan Zhong, Yuanyang Chen, Feng Shi, Shun Yuan Source Type: research