The multiphasic TNF- α-induced compromise of Calu-3 airway epithelial barrier function

Conclusion: TNF-α induced a multiphasic transepithelial leak in Calu-3 cell layers that was shown to be ERK mediated, as well as involve changes in the TJ complex. The micronutrients, retinoic acid and calcitriol, were effective at reducing this barrier compromise caused by TNF-α. The significance of these results for airway disease and for COVID-19 specifically are discussed.PMID:37000123 | DOI:10.1080/01902148.2023.2193637

Source: Experimental Lung Research - March 31, 2023 Category: Respiratory Medicine Authors: Katherine M DiGuilio Elizabeth Rybakovsky Yoongyeong Baek Mary Carmen Valenzano James M Mullin Source Type: research