Loss of CpG island immunity to DNA methylation induced by mutation

The inheritance of acquired traits in mammals is a highly controversial topic in biology. Recently, Takahashi et al. (Cell 186:715 –731, 2023) have reported that insertion of CpG-free DNA into a CpG island (CGI...

Source: Epigenetics and Chromatin - May 11, 2023 Category: Genetics & Stem Cells Authors: Bernhard Horsthemke and Adrian Bird Tags: Comment Source Type: research