BACE1 regulates expression of Clusterin in astrocytes for enhancing clearance of β-amyloid peptides

Abnormal accumulation of amyloid beta peptide (A β) in the brain induces a cascade of pathological changes in Alzheimer’s disease (AD), and inhibiting BACE1, which is required for Aβ generation, is therefore be...

Source: Molecular Neurodegeneration - May 4, 2023 Category: Neurology Authors: John Zhou, Neeraj Singh, James Galske, Jacob Hudobenko, Xiangyou Hu and Riqiang Yan Tags: Research article Source Type: research