Epithelial innate immune response to Pseudomonas aeruginosa –derived flagellin in chronic rhinosinusitis

ConclusionsFlagellin activates a potent innate immune response in HSNECs characterized by pro-inflammatory mediators and cytokines/chemokines associated with neutrophilic inflammation. HSNECs from CRS patients have a dysregulated innate immune response to flagellin characterized by an imbalance between IL-6 and TNF- α secretion.

Source: International Forum of Allergy and Rhinology - May 6, 2023 Category: Allergy & Immunology Authors: Ping Li, Quanhu Sheng, Li ‐Ching Huang, Justin H. Turner Tags: ORIGINAL ARTICLE Source Type: research