Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases

Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to predispose to neurodegeneration by enhancing protein aggregation. While a subset of α-synuclein, TDP-43 and tau mutations has been sho...

Source: Molecular Neurodegeneration - May 2, 2023 Category: Neurology Authors: Paul J. Sampognaro, Shruti Arya, Giselle M. Knudsen, Emma L. Gunderson, Angelica Sandoval-Perez, Molly Hodul, Katherine Bowles, Charles S. Craik, Matthew P. Jacobson and Aimee W. Kao Tags: Research article Source Type: research