An Overview of Nanoparticle Protein Corona Literature

As nanobiotechnologies have become more ubiquitously used in biotechnology, characterizing the protein corona has been critical to predict their in vivo outcomes. In this paper, the current protein corona literature is analyzed and several key advances and shortcomings are unearthed which are opined important to bring to light on various factors that affect the decoration of protein corona at the surface of nanoparticles. AbstractThe protein corona forms spontaneously on nanoparticle surfaces when nanomaterials are introduced into any biological system/fluid. Reliable characterization of the protein corona is, therefore, a vital step in the development of safe and efficient diagnostic and therapeutic nanomedicine products. 2134 published manuscripts on the protein corona are reviewed and a down-selection of 470 papers spanning 2000 –2021, comprising 1702 nanoparticle (NP) systems is analyzed. This analysis reveals: i) most corona studies have been conducted on metal and metal oxide nanoparticles; ii) despite their overwhelming presence in clinical practice, lipid-based NPs are underrepresented in protein corona research, iii ) studies use new methods to improve reliability and reproducibility in protein corona research; iv) studies use more specific protein sources toward personalized medicine; and v) careful characterization of nanoparticles after corona formation is imperative to minimize the role of aggregation and p rotein contamination on corona outcomes. As nanopartic...
Source: Small - Category: Nanotechnology Authors: Tags: Review Source Type: research