Function and targeting of MALT1 paracaspase in cancer

Human MALT1 (mucosa associated lymphoid tissue protein 1) was originally identified from the translocation breakpoint t(11;18)(q21;q21), which is found predominantly in late-stage MALT lymphomas [1,2]. Sequence comparisons of MALT1 indicated an enzymatic function of the paracaspase domain that comprises a caspase-like fold as found in caspases [3]. Thus, MALT1 (also termed PCASP1) is the founding and only human member of the paracaspase family of cysteine proteases [4], raising considerable interest in MALT1 as a drug target.
Source: Cancer Treatment Reviews - Category: Cancer & Oncology Authors: Tags: Anti-tumour Treatment Source Type: research