Targeting the Elevated IFN- γ in Vitiligo Patients by Human Anti- IFN-γ Monoclonal Antibody Hampers Direct Cytototoxicity in Melanocyte

Vitiligo is an autoimmune disease that progressively destroys melanocytes in the skin, resulting in patchy disfiguring depigmentation. The direct pathological effect of IFN- γ, CXCL10 to the melanocytes in vitiligo has been reported, but there are contradictory results to which cytokine exerts the critical cytotoxic effect on melanocytes.

Source: Journal of Dermatological Science - April 24, 2023 Category: Dermatology Authors: Chau Yee Ng, Yu-Pei Chan, Yen-Chuan Chiu, Han-Po Shih, You-Ning Lin, Pei-Han Chung, Jing-Yi Huang, Hung-Kai Chen, Wen-Hung Chung, Cheng-Lung Ku Source Type: research