Prognostic role of CDKN2A deletion and p53 expression and association with MIPIb in Mantle Cell Lymphoma

In this study, we investigated the prognostic role of MIPIb and the association with biological markers including SOX11, p53 expression, Ki-67 and CDKN2A.This retrospective study was focused on 23 patients with newly diagnosed classical MCL, treated at the University Hospital of Bari (Italy) between January 2006 and June 2019.We identified a MIPIb value ≥ 5.4440 as a prognostic parameter that correlates with p53 expression and CDKN2A deletion.

Source: Clinical Lymphoma, Myeloma and Leukemia - April 19, 2023 Category: Hematology Authors: Francesco Gaudio, Michele Dicataldo, Fabrizia Di Giovanni, Gerardo Cazzato, Antonio d'Amati, Tommasina Perrone, Pierluigi Masciopinto, Filomena Emanuela Laddaga, Pellegrino Musto, Eugenio Maiorano, Giuseppe Ingravallo Tags: Original Study Source Type: research