Hepatitis B virus reactivation in patients receiving Bruton tyrosine kinase inhibitors

: Bruton tyrosine kinase (BTK) inhibitors are used to treat B-cell hematologic malignancies. Ibrutinib has been associated with hepatitis B virus (HBV) reactivation. We sought to identify patients with hematologic malignancies who developed HBV reactivation after receiving first-generation (ibrutinib) or second-generation (acalabrutinib and zanubrutinib) BTK inhibitors.

Source: Clinical Lymphoma, Myeloma and Leukemia - April 19, 2023 Category: Hematology Authors: Chia-Yu Chiu, Sairah Ahmed, Sheeba K. Thomas, Lan Sun Wang, Khalis Mustafayev, Luis E. Fayad, William G. Wierda, Fareed Khawaja, Harrys A. Torres Tags: Original Study Source Type: research