1593 The senolytic flavonoid compound fisetin extends lifespan in murine recessive dystrophic epidermolysis bullosa

The process of cellular senescence involves stable exit from the cell cycle with downstream induction of a pro-inflammatory secretory phenotype. Specific senescence targeting drugs, referred to as senolytics, have the capacity to induce apoptosis in senescent cells. Given the potential for an increased cellular senescent profile in Recessive Dystrophic Epidermolysis Bullosa (RDEB), we questioned whether the senolytic preparation, fisetin, might prolong survival in a mouse model. An established hypomorphic mouse model of RDEB, on a hybrid background of C57BL/6:129sv, was used in concordance with University of Minnesota IACUC guidelines.

Source: Journal of Investigative Dermatology - April 17, 2023 Category: Dermatology Authors: W.C. Miller, C. Popp, C. Strege, W. Stone, C. Eide, K. Bui, C.L. Ebens, J.A. McGrath, J. Tolar Source Type: research