Prevention of recurrent preeclampsia in high-risk pregnancies: Is it time for a paradigm shift?

Statins are the class of drugs traditionally used to treat hyperlipidemia. Owing to the association of preeclampsia and high maternal hyperlipidemia and its ability to reverse an angiogenic imbalance and correct endothelial dysfunction, pravastatin (hydrophilic statin) has been used to prevent or treat preeclampsia during pregnancy. Although pravastatin has been demonstrated to have preventative effects in preeclampsia model mice without negatively affecting offspring outcomes, and the Food and Drug Administration removed the “Pregnancy Category X” label for statins, their safety concerning the fetus is still of concern.
Source: American Journal of Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Letter to the Editors Source Type: research