Oncostatin M stimulates prostaglandin D2-induced osteoprotegerin and interleukin-6 synthesis in osteoblasts

Fracture healing consists of inflammation and bone repair processes. Several stages, including the recruitment of mesenchymal progenitor cells to the fracture site and their differentiation into osteoblasts and subsequent bone remodeling initiated by osteoclasts, are widely known in fracture healing processes [1]. During these processes, macrophages are present at multiple stages and play a pivotal role in bone formation as well as osteoblasts [1]. Oncostatin M, an inflammatory cytokine belonging to the interleukin-6 (IL-6) superfamily, is recognized as a product of macrophages [2].
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - Category: Biomedical Science Authors: Tags: Original research article Source Type: research