In vivo evolution to echinocandin resistance and increasing clonal heterogeneity in Candida auris during a difficult-to-control hospital outbreak, Italy, 2019 to 2022

A difficult-to-control outbreak ofCandida auris is ongoing in a large tertiary care hospital in Liguria, Italy, where it first emerged in 2019. In a retrospective analysis, 503 cases ofC. auris carriage or infection were observed between July 2019 and December 2022. Genomic surveillance identified putative cases that no longer occurred as part of one defined outbreak and the emergence of echinocandin (pandrug) resistance following independent selection ofFKS1S639F andFKS1F635Y mutants upon prolonged exposure to caspofungin and/or anidulafungin.

Source: Eurosurveillance - April 6, 2023 Category: Infectious Diseases Authors: Giulia Codda, Edward Willison, Laura Magnasco, Paola Morici, Daniele Roberto Giacobbe, Antonella Mencacci, Daniele Marini, Malgorzata Mikulska, Matteo Bassetti, Anna Marchese and Vincenzo Di Pilato Source Type: research