Keratinocyte PIEZO1 Contributes To Peripheral Sensitization In A Rat Model Of Complex Regional Pain Syndrome

Patients suffering from complex regional pain syndrome (CRPS) often present with debilitating mechanical allodynia in the skin of the affected limb. To explore the mechanism underlying peripheral nociceptive sensitization in CRPS and seek therapies targeting the periphery without affecting the central nervous system, we studied the role of keratinocyte mechanosensitive PIEZO1 channel in CRPS models. We induced ischemia-reperfusion (I/R) injury for establishing in vivo chronic post-ischemia pain (CPIP) rat model and in vitro oxygen-glucose deprivation reperfusion (OGD/R) cultured cell model to mimic CRPS.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research