New benzoquinone pigments from the hydnoid fungus < em > Sarcodontia setosa < /em > and their biosynthetic relationship

Nat Prod Res. 2023 Apr 2:1-10. doi: 10.1080/14786419.2023.2195176. Online ahead of print.ABSTRACTChemical investigation of the hydnoid fungus Sarcodontia setosa resulted in the isolation of five compounds, including two new sarcodontic acid derivatives - setosic acid (1) and 7,8-dehydrohomosarcodontic acid (2) along with three known benzoquinone pigments - sarcodontic acid (3), 4,5-dehydrosarcodontic acid (4) and dihydrosarcodontic acid (5). The structures were elucidated using spectroscopic methods (UV, NMR and HR-ESIMS). The biosynthetic relationship of the isolated compounds is proposed and discussed. Antibacterial activity screening of compounds 1-5 against ESKAPE bacterial strains in vitro with zones of inhibition was performed and MIC values were established for the most active compounds (3 and 5).PMID:37004996 | DOI:10.1080/14786419.2023.2195176

Source: Natural Product Research - April 2, 2023 Category: Biochemistry Authors: Andrei K Whaley Anastasiia O Ponkratova Anastasia A Orlova Sergey V Volobuev Natalia V Shakhova Evgeny B Serebryakov Sergey N Smirnov Natalia V Pustovit Liudmila A Kraeva Vladimir G Luzhanin Source Type: research