Cerebrospinal fluid lipoproteins inhibit α-synuclein aggregation by interacting with oligomeric species in seed amplification assays

Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson’s disease (PD) and other synucleinopathies. Currently, α-syn seed amplification assays (SAAs) using cerebrospinal fluid (CSF) represent th...

Source: Molecular Neurodegeneration - April 1, 2023 Category: Neurology Authors: Giovanni Bellomo, Silvia Paciotti, Luis Concha-Marambio, Domenico Rizzo, Anna Lidia Wojda ƚa, Davide Chiasserini, Leonardo Gatticchi, Linda Cerofolini, Stefano Giuntini, Chiara Maria Giulia De Luca, Yihua Ma, Carly M. Farris, Giuseppe Pieraccini, Sara Bo Tags: Research article Source Type: research