Corneal Biomechanical Properties of various types of glaucoma and their impact on measurement of intraocular pressure

Introduction Corneal biomechanical properties could affect intraocular pressure (IOP) measurement. To evaluate the differences of corneal biomechanical properties of various types of glaucoma, assess their effect on IOP measurements. Methods An observational clinical study of 486 subjects including 102 normal subjects, 104 ocular hypertension (OHT), 89 normal tension glaucoma (NTG) and 191 high tension glaucoma (HTG). Corneal biomechanical parameters were measured using ocular response analyzer (ORA). The main parameters assessed were corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated pressure measurement (IOPg) and corneal compensated intraocular pressure (IOPcc). Ultrasound pachymetry was used to measure central corneal thickness (CCT). IOP was measured by Goldmann applanation tonometer (GAT) and non-contact tonometer (NCT). Visual field (VF) and refractive status were also recorded. Results were analyzed by One-way analysis of variance, univariate and multivariate linear regression analyses, and Bland-Altman plots. Results 
 Multiple comparison by ANOVA showed significantly lower CH and CRF in NTG compared to HTG, OHT and normal subjects (CH:0.011, 0.015 and 0.033, CRF: 0.001,
Source: Ophthalmic Research - Category: Opthalmology Source Type: research