Blockade of CD122 on Memory T cells in the Skin Suppresses Sclerodermatous Graft-versus-host Disease

Antigen-stimulated na ïve T cells differentiate into effector and memory T cells, of which resident memory T (TRM) cells reside permanently in organ tissues. Involvement of TRM cells has been indicated in pathological conditions of various skin diseases. CD122, which is the β chain subunit of interleukin (IL)-2 and IL- 15 receptors, is expressed on immune cells including TRM cells.

Source: Journal of Dermatological Science - March 20, 2023 Category: Dermatology Authors: Noriko Kubota, Ryota Tanaka, Yuki Ichimura, Risa Konishi, J Yun Tso, Naoya Tsurushita, Toshifumi Nomura, Naoko Okiyama Source Type: research