Breakthrough in tinnitus research could lead to testable model

A major breakthrough has been made that provides new insights into how tinnitus, and the often co-occurring hyperacusis, might develop and be sustained. Tinnitus is largely a mystery, a phantom sound heard in the absence of actual sound. Tinnitus patients "hear" ringing, buzzing or hissing in their ears much like an amputee might "feel" pain in a missing limb. It is a symptom, not a disease, and though exposure to loud noise may cause it, some cases have no apparent trigger.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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AbstractAs research on the cognitive impact of medical conditions and mental health disorders advances, it is imperative for forensic neuropsychologists to stay abreast of rapidly accumulating new empirical evidence from neuroscience and neuropsychology to disentangle multiple determinants of cognitive impairment. Although medicolegal neuropsychological assessments traditionally focused on traumatic brain injury (TBI) sequelae, it is equally important to consider the potential impact of any other acquired, or secondarily induced brain impairments, regardless of their source. Such injuries or conditions are at times assumed...
Source: Psychological Injury and Law - Category: Medical Law Source Type: research
AbstractAn endolymphatic sac tumor (ELST) is a rare, indolent but locally aggressive tumor arising in the posterior petrous ridge. Patients present with sensorineural hearing loss and tinnitus. As the tumor progresses, patients may experience vertigo, ataxia, facial nerve paresis, pain and otorrhea. Most patients present in their 4th or 5th decade with a wide age range. Patients with von Hippel –Lindau disease have an increased likelihood of developing ELST. Histologically, ELST is a low-grade adenocarcinoma. As it progresses, it destroys bone and extends into adjacent tissues. The likelihood of regional or distant m...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS: Results indicate that musicians working in Turkish state symphony orchestras encounter numerous health problems (tinnitus, hearing loss, musculoskeletal symptoms, etc.) due to their profession. No specific health support is provided, especially education and health service provision. PMID: 29868686 [PubMed - in process]
Source: Medical Problems of Performing Artists - Category: Sports Medicine Tags: Med Probl Perform Art Source Type: research
We present a case report on Cycloserine induced Suicidal tendencies and Kanamycin induced decrease in hearing sensation in Indian MDR-TB patient. CASE REPORT: A 55-year-old male patient who was diagnosed with MDR-TB was prescribed with category IV anti-tubercular therapy. Within one month of initiation of therapy, he developed repeated suicidal thoughts, joint pain, restlessness, depression, constipation, insomnia, tinnitus and a decrease in hearing sensation. RESULTS: Cycloserine and kanamycin were closely associated with suicidal tendency and tinnitus followed by decrease in hearing sensations respectively. On ...
Source: Current Drug Safety - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Saf Source Type: research
CONCLUSIONS: IHS is a rare entity with a difficult diagnosis. It requires high quality neuroimaging tests for its detection and early treatment. The evaluation of both techniques, MRI and Radionuclide cisternography, allow to specifically determinate the level of CSF leakage. EBP-guided imaging, according to clinical practice, provides a better chance of therapeutic success compared to a blind performance.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Neurology & amp; Psychiatry Imaging Posters Source Type: research
This article reports a case of exploding head syndrome (EHS) as an aura of migraine with brainstem aura (MBA). A middle-aged man presented with intermittent episodes of a brief sensation of explosion in the head, visual flashing, vertigo, hearing loss, tinnitus, confusion, ataxia, dysarthria, and bilateral visual impairment followed by migraine headache. The condition was diagnosed as MBA. Explosive head sensation, sensory phenomena, and headaches improved over time with nortriptyline. This case shows that EHS can present as a primary aura symptom in patients with MBA. PMID: 29694468 [PubMed - in process]
Source: Journal of Orofacial Pain - Category: ENT & OMF Tags: J Oral Facial Pain Headache Source Type: research
Publication date: Available online 6 April 2018 Source:Journal of Taibah University Medical Sciences Author(s): Sylves Patrick, Hui-Tze Chan, Wan Hazabbah Wan Hitam, Zunaina Embong, Yaakub Azhany, Liza-Sharmini Ahmad Tajudin Management of inflammation after surgery for recalcitrant anterior uveitis is challenging. Herein, we report successful treatment using intracameral injection of recombinant tissue plasminogen activator (rtPA) in two patients with recalcitrant anterior uveitis, due to infective uveitis and Vogt–Koyanagi–Harada disease, respectively. A 40-year-old woman presented with bilateral redness and ...
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
This study describes characteristics of FMD patients with and without A and/or D (A/D).Methods: Patients enrolled in the US Registry for FMD between 2009-2017 and had A/D information were analyzed (n=985). Diagnosis of A/D was ascertained from patient charts or self-reported via medical history questionnaires at time of registry enrollment. Demographics, family history, past medical history, presenting symptoms, and affected vascular beds were compared between patients with and without A/D.Results: A total of 351 (35.6%) had A/D. Of patients with A/D, 126 (35.9%) had both. Patients with A/D were more likely to have a famil...
Source: Circulation: Cardiovascular Quality and Outcomes - Category: Cardiology Authors: Tags: Session Title: Poster Session AM Source Type: research
Progress in drug development has brought a host of novel agents for the treatment of neurological disorders ranging from multiple sclerosis to chronic pain. However, the treatment of most neurological disorders is still dependent on older medications. This includes medications, such as carbamazepine, with clinical activity across a broad number of disorders. Carbamazepine was first approved in 1963 for the treatment of epilepsy but has been used for treating types of schizophrenia, bipolar disorder, neuropathic pain, tinnitus, and trigeminal neuralgia. Although this agent is safe and effective for many patients, there is a...
Source: JAMA Neurology - Category: Neurology Source Type: research
Abstract BACKGROUND Tocainide is an antiarrhythmic agent belonging to class IB that was primarily used for suppression of symptomatic ventricular arrhythmias. Tocainide was also reported to relieve pain such as tic douloureux, trigemina neuralgia in humans and tinnitus. Significant antinociception, as assayed on the hot-plate test, was observed after intraperitoneal injection of tocainide, too. By the mid-1980s tocainide was emerging as a more consistently effective treatment for myotonic disorders. Numerous reports of serious adverse reactions led to the use of tocainide being discontinued, even though research o...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research
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