Variant curation and interpretation in hereditary cancer genes: An institutional experience in Latin America

ConclusionsMost VUS were reclassified as benign/likely benign. Since false-positive and -negative results can be obtained with automated tools, manual curation should also be used as a complement. Our results contribute to improving cancer risk assessment and management for a broad range of hereditary cancer syndromes in Hispanic/Latino populations.

Source: Molecular Genetics & Genomic Medicine - March 11, 2023 Category: Genetics & Stem Cells Authors: Mar ía Carolina Manotas, Ana Lucia Rivera, María Carolina Sanabria‐Salas Tags: ORIGINAL ARTICLE Source Type: research