Reduction of Anti-A and Anti-B Isoagglutinin Titers of Group O Whole Blood Units Employing an ABO Antibody Immune Adsorption Column

Massive hemorrhage is a leading cause of death from trauma. There is growing interest in group O whole blood transfusions to mitigate coagulopathy and hemorrhagic shock. Insufficient availability of low-titer group O whole blood is a barrier to routine use. We tested the efficacy of the Glycosorb ® ABO immunoadsorption column to reduce anti-A/B titers in group O whole blood.

Source: Transfusion and Apheresis Science - March 3, 2023 Category: Hematology Authors: Gaurav K. Gupta, Kelly Henrichs, Kurt Nilsson, Stephen Wagner, Bethany Brown, Debra Masel, Mark L. Gestring, Michael A. Vella, Majed A. Refaai, Neil Blumberg Source Type: research