Greater resistance to footshock punishment in female C57BL/6J mice responding for ethanol

CONCLUSIONS: Females continue to respond for 10% ethanol despite a 0.35 mA footshock, and this behavior is not due to differences in footshock sensitivity between males and females. These results show that female C57BL/6J mice are generally more resistant to punishment in an operant self-administration paradigm. The findings add to the literature characterizing aversion-resistant alcohol-drinking behaviors in females.PMID:36822578 | DOI:10.1111/acer.15039

Source: Alcoholism, Clinical and Experimental Research - February 23, 2023 Category: Addiction Authors: Elizabeth A Sneddon Kaila A Fennell Sachi Bhati Joshua E Setters Kristen M Schuh Jenelle N DeMedio Brandon J Arnold Sean C Monroe Jennifer J Quinn Anna K Radke Source Type: research