Bi-allelic variants in WNT7B disrupt the development of multiple organs in humans

Conclusion
Our findings indicate that defective WNT7B function underlies a form of lung hypoplasia that is associated with the PDAC syndrome, and provide evidence for involvement of the WNT–β-catenin pathway in human lung, tracheal, ocular, cardiac, and renal development.

Source: Journal of Medical Genetics - February 23, 2023 Category: Genetics & Stem Cells Authors: Bouasker, S., Patel, N., Greenlees, R., Wellesley, D., Fares Taie, L., Almontashiri, N. A., Baptista, J., Alghamdi, M. A., Boissel, S., Martinovic, J., Prokudin, I., Holden, S., Mudhar, H.-S., Riley, L. G., Nassif, C., Attie-Bitach, T., Miguet, M., Delous Tags: Developmental defects Source Type: research