The gut microbiota promotes distal tissue regeneration via ROR γ+ regulatory T cell emissaries

Colonic ROR γ+ Treg cells are a specialized microbiota-dependent population crucial for intestinal homeostasis, but their role in extra-gut tissues remains unexplored. Hanna et al. report that these cells seed non-mucosal tissues in response to injury wherein they can rein in IL-17A-driven inflammation, regul ate stem cell activities, and promote tissue regeneration.

Source: Immunity - February 22, 2023 Category: Allergy & Immunology Authors: Bola S. Hanna, Gang Wang, Silvia Galv án-Peña, Alexander O. Mann, Ricardo N. Ramirez, Andrés R. Muñoz-Rojas, Kathleen Smith, Min Wan, Christophe Benoist, Diane Mathis Tags: Article Source Type: research