Penalized Logistic Regression Analysis for Genetic Association Studies of Binary Phenotypes

Conclusion: We have proposed a method for single rare variant analysis with binary phenotypes by logistic regression penalized by log-F priors. Our method has the advantage of being easily extended to correct for confounding due to population structure and genetic relatedness through a data augmentation approach.Hum Hered 2022;87:69 –86

Source: Human Heredity - June 29, 2022 Category: Genetics & Stem Cells Source Type: research