Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis

The impact of liver stage Plasmodium infection on clinical outcomes of malaria is underappreciated. Chora et  al. demonstrate an important role in liver stage-dependent activation of γδ T cells and further show that the integration of host responses during both liver and blood stages of infection dictates malaria severity.

Source: Immunity - February 17, 2023 Category: Allergy & Immunology Authors: Ângelo Ferreira Chora, Sofia Marques, Joana Lisboa Gonçalves, Priscila Lima, Daniel Gomes da Costa, Daniel Fernandez-Ruiz, Maria Inês Marreiros, Pedro Ruivo, Tânia Carvalho, Ruy M. Ribeiro, Karine Serre, William R. Heath, Bruno Silva-Santos, Ann T. Ta Tags: Article Source Type: research