Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes

Intestinal IEL homeostasis relies on AHR, a ligand-induced transcription factor that is tightly controlled through feedback circuitries. Panda et  al. demonstrated that lack of AHR repressor (AHRR) unleashes the AHR-induced monooxygenase CYP1A1, which causes oxidative stress and ferroptosis of IELs. This loss of IELs can be reversed by dietary antioxidants.

Source: Immunity - February 16, 2023 Category: Allergy & Immunology Authors: Santosh K. Panda, Vincent Peng, Raki Sudan, Alina Ulezko Antonova, Blanda Di Luccia, Takahiro E. Ohara, Jose Luis Fachi, Gary E. Grajales-Reyes, Natalia Jaeger, Tihana Trsan, Susan Gilfillan, Marina Cella, Marco Colonna Tags: Article Source Type: research