Broadly neutralizing anti-S2 antibodies protect against all three human betacoronaviruses that cause deadly disease

Pan-betacoronavirus broadly neutralizing antibodies (bnAbs) may hold key to developing broadly protective vaccines against pandemic coronaviruses and SARS-CoV-2 variants. Zhou et al. isolate a large panel of S2 stem-helix bnAbs to betacoronaviruses and reveal their public features. Select stem-helix bnAbs protect against all three human betacoronaviruses that cause deadly disease.

Source: Immunity - February 15, 2023 Category: Allergy & Immunology Authors: Panpan Zhou, Ge Song, Hejun Liu, Meng Yuan, Wan-ting He, Nathan Beutler, Xueyong Zhu, Longping V. Tse, David R. Martinez, Alexandra Sch äfer, Fabio Anzanello, Peter Yong, Linghang Peng, Katharina Dueker, Rami Musharrafieh, Sean Callaghan, Tazio Capozzola Tags: Article Source Type: research