EDC exposure in 3D genome memory in transgenerational obesity

Nature Reviews Endocrinology, Published online: 15 February 2023; doi:10.1038/s41574-023-00810-xA new study reveals that exposure of pregnant mice to an endocrine disrupting chemical, bisphenol A, induces multi-transgenerational (up to six) inheritance of obesity in their descendants. This effect depends on CTCF-dependent chromatin reorganization in the sperm, a synergistic outcome of altered DNA methylation, RNA modification and long-range chromatin interactions.
Source: Nature Reviews Endocrinology - Category: Endocrinology Authors: Source Type: research