Interhemispheric parietal cortex connectivity reflects improvement in post-stroke spasticity due to treatment with botulinum toxin-A

In post-stroke spasticity (PSS), effective treatment with botulinum neurotoxin (BoNT) is associated with transient decrease in activation of the ipsilesional superior parietal lobule (SPL) and intraparietal sulcus (IPS). We hypothesized that this would be reflected in changes in resting-state functional connectivity (rsFC) of the SPL/IPS. Our aim was therefore to assess rsFC of the ipsilesional SPL/IPS in chronic stroke patients with hemiparesis both with and without PSS and to explore the relationship between SPL/IPS rsFC and PSS severity.

Source: Journal of the Neurological Sciences - February 14, 2023 Category: Neurology Authors: Tom áš Veverka, Pavel Hok, Markéta Trnečková, Pavel Otruba, Jana Zapletalová, Zbyněk Tüdös, Martin Lotze, Petr Kaňovský, Petr Hluštík Source Type: research