A novel somatic mutation in POLE exonuclease domain associated with ultra-mutational signature and MMR deficiency in endometrial cancer: a case report

Defect in proofreading exonuclease activity of polymerases epsilon and delta (Pols ε and δ) leads to mutagenesis and genomic instability and has been described in several cancer types. Somatic POLE exonuclease do...

Source: Diagnostic Pathology - February 10, 2023 Category: Pathology Authors: Jiantao Cui, Xiuying Chen, Qian Zhai, Na Chen, Xiaodan Li, Yuli Zhang, Hui Wang, Xin Bian, Na Gao, Deyi Chen, Zhihong Chen, Shibiao Zhang and Yan Chen Tags: Case Report Source Type: research