Sudden Cardiac Death Risk Stratification of the Early Repolarization Syndrome: An Updated Review of the Literature

AbstractPurpose of ReviewEarly repolarization syndrome (ERS), once thought to be innocuous, has now been shown  to be responsible for ventricular arrythmias and sudden cardiac death occurrence. This review will help the clinician to identify the patients who are most at risk for arrhythmias, so that they can adopt a preventive or secondary treatment approach, either of which is still poorly defined.Recent FindingsPatients at high risk are found to be particularly young men, with a personal or family history of syncope or sudden death, who have an inferolateral ER on the electrocardiogram, more elevated J-point, longer J-wave duration and wider J angle, a horizontal or descending ST segment, lower T/R ratio, and small and/or inverted waves. The association with a structural heart disease or another channelopathy potentiates this arrhythmic risk.SummaryTaken together, these parameters allow prediction of the malignancy of ER pattern with a certain reliability. Further research is however needed to develop concrete risk stratification algorithms and the therapeutic strategies taken in function of it.

Source: Current Cardiology Reports - February 10, 2023 Category: Cardiology Source Type: research