Selective IgG2 ‐deficiency in yellow nail syndrome

We present a case of isolated IgG2-deficiency in a patient with Yellow Nail Syndrome (YNS), manifested by yellow-green nails, bilateral pleural effusions, pericardial effusion, bronchiectasis, and lower extremity edema. Given the rarity of the condition (estimated prevalence<1/1,000,000) and lack of thorough population-based studies, association of new or rare manifestations with YNS relies heavily on individual case reports. Key messageIgG2-deficiency increases susceptibility to recurrent pulmonary infections and the risk for bronchiectasis. Isolated IgG2-deficiency has not been previously described in Yellow Nail Syndrome (YNS).

Source: Respirology Case Reports - February 10, 2023 Category: Respiratory Medicine Authors: Steven Tessier, Santo Longo, Firas Ido Tags: CLINICAL IMAGE Source Type: research