Pathogen exposure misclassification can bias association signals in GWAS of infectious diseases when using population-based common control subjects
Pathogen exposure is a necessary but insufficient cause of infectious disease. Through simulation and empirical genome-wide association comparisons, Duchen et al. show that ignoring pathogen exposure can bias genetic associations. Control selection is important to accurately characterize the genetics underlying outcomes conditional upon environmental exposures, including infectious diseases.
Source: The American Journal of Human Genetics - Category: Genetics & Stem Cells Authors: Dylan Duchen, Candelaria Vergara, Chloe L. Thio, Prosenjit Kundu, Nilanjan Chatterjee, David L. Thomas, Genevieve L. Wojcik, Priya Duggal Tags: Article Source Type: research