Using genetic association data to guide drug discovery and development: Review of methods and applications

Mendelian randomization exploits naturally occurring randomization in the transmission of genetic variants to mimic randomized trials in observational data. We review statistical methods and applications to showcase opportunities for applying Mendelian randomization in guiding pharmaceutical development efforts to target the right mechanism in the right population at the right time.

Source: The American Journal of Human Genetics - February 2, 2023 Category: Genetics & Stem Cells Authors: Stephen Burgess, Amy M. Mason, Andrew J. Grant, Eric A.W. Slob, Apostolos Gkatzionis, Verena Zuber, Ashish Patel, Haodong Tian, Cunhao Liu, William G. Haynes, G. Kees Hovingh, Lotte Bjerre Knudsen, John C. Whittaker, Dipender Gill Tags: Review Source Type: research