Germline TP53 pathogenic variants and breast cancer: a narrative review

Breast cancer is the most common cancer diagnosis in women and the majority are considered sporadic cases [1]. Around 10% of breast malignancies are associated with a germline pathogenic variant in one of the breast cancer susceptibility genes and family history is often the telltale of an underlying inherited predisposition [2,3]. BRCA1 and BRCA2 pathogenic variants are responsible for less than half of the variants involved in increased breast cancer risk and pathogenic variants in multiple other breast cancer predisposing genes, including TP53, are responsible for the remaining [4 –6].

Source: Cancer Treatment Reviews - January 30, 2023 Category: Cancer & Oncology Authors: Eva Blondeaux, Luca Arecco, Kevin Punie, Rossella Graffeo, Angela Toss, Carmine De Angelis, Lucia Trevisan, Giulia Buzzatti, Sabine C. Linn, Peter Dubsky, Mara Cruellas, Ann H. Partridge, Judith Balma ña, Shani Paluch-Shimon, Matteo Lambertini Tags: Tumour Review Source Type: research