Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis

The trajectory from healthy to critical illness is influenced by numerous factors, including metabolism, which differs substantially between males and females. Whole body protein breakdown is substantially increased in critically ill patients, but it remains unclear whether there are sex differences that could explain the different health outcomes. Hence, we performed a secondary analysis of a study, where we used a novel pulse isotope method in critically ill and matched healthy males and females.

Source: Metabolism - Clinical and Experimental - January 26, 2023 Category: Biomedical Science Authors: Nicolaas E.P. Deutz, Pierre Singer, Raven A. Wierzchowska-McNew, Marina V. Viana, Itai A. Ben-David, Olivier Pantet, John J. Thaden, Gabriella A.M. Ten Have, Mari ëlle P.K.J. Engelen, Mette M. Berger Source Type: research