Two new β-carboline alkaloids from the roots of Anemone altaica

AbstractTwo newβ-carboline alkaloids, anemonilins A and B (1–2), and two knownβ-carboline alkaloids, flazine (3) and 4-(9H-β-carbolin-l-yl)-4-oxo-butyric acid (4), were isolated from the roots ofAnemone altaica. The structures of the isolated compounds were elucidated with spectroscopic and spectrometric methods (1D and 2DNMR, HRESIMS). Compounds2 and4 significantly attenuated the growth inhibition induced by lipopolysaccharide (LPS) in normal rat kidney tubule epithelioid (NRK52e) cells (p< 0.05 orp< 0.01). Furthermore, compound2 significantly reduced the apoptosis (p< 0.05) and the caspase-3/9 expression of NRK52e cells induced by LPS.Graphical abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research