Extracellular mitochondria drive CD8 T cell dysfunction in trauma by upregulating CD39

Conclusion
These studies in experimental models and in a cohort of trauma patients reveal important associations between extracellular mitochondria, aberrant purinergic signalling and immune dysfunction. These pathogenic factors with immune exhaustion are linked to SIRS and could be targeted therapeutically.

Source: Thorax - January 12, 2023 Category: Respiratory Medicine Authors: Tiwari-Heckler, S., Lee, G. R., Harbison, J., Ledderose, C., Csizmadia, E., Melton, D., Zhang, Q., Junger, W., Chen, G., Hauser, C. J., Otterbein, L. E., Longhi, M. S., Robson, S. C. Tags: Thorax Critical care Source Type: research