Comparability of C-Peptide Measurements – Current Status and Clinical Relevance
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1998-6889C-peptide is an increasingly used and established marker for beta cell function
by assessing endogenous insulin secretion. Accurate and comparable C-peptide
measurements are needed in clinical practice and research studies. For example,
to calculate HOMA-indices, the C-peptide/glucose ratio, and the
classification of recently published novel subgroups of diabetes and prediabetes
have used C-peptide measurements. Although the process for standardization of
C-peptide measurements is advanced, its full implementation is still missing;
therefore, the current status of the comparability of C-peptide measurements
using different immunoassays is unclear. Here we compared five widely used
C-peptide immunoassays on different analyzers (Abbott ALINITY i, DiaSorin
Liaison XL, Roche Cobas e411, Siemens Healthineers ADVIA Centaur XPT, and
Immulite 2000 XPi) using serum samples covering the clinically relevant
C-peptide concentration range. Although all investigated immunoassays are
traceable to the international reference reagent for C-peptide (NIBSC code:
84/510), results of C-peptide measurements showed significant
differences between analyzers in the entire concentration range, especially with
increasing C-peptide concentrations. The mean bias was largest (36.6%)
bet...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: H örber, Sebastian Orth, Matthias Fritsche, Andreas Peter, Andreas Tags: Article Source Type: research