Biomarkers predict hemorrhagic transformation and stroke severity after acute ischemic stroke

Hemorrhagic transformation (HT) is a complication occurring in patients with acute ischemic stroke (AIS) either spontaneously or post-thrombolysis leading to significant morbidity and mortality. We assessed circulating matrix metalloproteinase-9 (MMP-9), Claudin-5, and soluble serum stimulation-2 (sST2) in HT and stroke severity in AIS based on their temporal distribution.

Source: Journal of Stroke and Cerebrovascular Diseases - November 14, 2022 Category: Neurology Authors: Soumya Krishnamoorthy, P.N. Sylaja, Sapna Erat Sreedharan, Gurpreet Singh, Deepa Damayanthi, Srinivas Gopala, UK Madhusoodanan, Harikrishnan Ramachandran Source Type: research