Inhibition of S100A8/A9 ameliorates renal interstitial fibrosis in diabetic nephropathy

Renal interstitial fibrosis (RIF) is one of the main features of diabetic nephropathy (DN), but the molecular mechanisms mediating RIF in DN has yet been fully understood. S100A8 and S100A9 are the proteins associated with immune and inflammation response. Here we reported the expression of S100A8 and S100A9 were significantly increased on tubular epithelial cells in diabetic kidneys through a proteomic analysis.

Source: Metabolism - Clinical and Experimental - December 11, 2022 Category: Biomedical Science Authors: Lei Du, Yibing Chen, Jiasen Shi, Xiujuan Yu, Jieling Zhou, Xue Wang, Liu Xu, Junjie Liu, Jian Gao, Xiaoke Gu, Tao Wang, Zeyuan Yin, Chenglin Li, Meng Yan, Jianyun Wang, Xiaoxing Yin, Qian Lu Source Type: research