Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies

The genes and alleles of the antigen receptor loci are highly variable between individuals, which may affect the quality of the immune response to different pathogens. Here, Pushparaj et. al. use immunoglobulin genotyping and monoclonal antibody engineering to illustrate how heritable differences in such genes can modulate anti-SARS-CoV-2 antibody function.

Source: Immunity - December 11, 2022 Category: Allergy & Immunology Authors: Pradeepa Pushparaj, Andrea Nicoletto, Daniel J. Sheward, Hrishikesh Das, Xaquin Castro Dopico, Laura Perez Vidakovics, Leo Hanke, Mark Chernyshev, Sanjana Narang, Sungyong Kim, Julian Fischbach, Simon Ekstr öm, Gerald McInerney, B. Martin Hällberg, Ben Tags: Article Source Type: research